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mzmolly

(52,609 posts)
Sun Dec 21, 2025, 12:41 PM Dec 21

More Than Just a High: The Cannabis-Schizophrenia Link - YALE School of Medicine

The link between cannabis and its effects on mental health, particularly schizophrenia, continues to spark debate. While many tout marijuana’s calming effects, particularly in online forums, mental health experts caution against its use—especially among young people. Research increasingly reveals a concerning relationship between cannabis use and psychotic disorders like schizophrenia.

Beyond the “high” associated with marijuana, many users report paranoia or hallucinations while under the influence. This is due to the active component, Tetrahydrocannabinol (THC). THC binds to receptors in the brain and triggers a series of reactions in brain cells. Typically, these effects fade after the high wears off, but in some cases, they may last longer, leading to what’s known as cannabis-induced psychosis.

In high-risk individuals, cannabis can disrupt brain development and lead to conditions like schizophrenia—a severe mental illness characterized by long-term hallucinations, delusions, and paranoia. A Finnish study of 18,000 individuals with cannabis-induced psychosis found that nearly 50% were later diagnosed with schizophrenia (1). Other studies confirm that regular use, especially of high-potency products, increases the risk of developing schizophrenia by four times (2). This risk is comparable to the relationship between high cholesterol and heart disease.

The Specialized Treatment Early in Psychosis (STEP) program at Yale found that over 75% of patients with early schizophrenia had a history of cannabis use, further cementing this link (3).


More at: YALE School of Medicine

I'm sharing this as a caution, in part due to the tragedy of Rob Reiner. His son was of the impression that he could be 'California sober' and continue to use weed, without any ill effects. While this may be true for most, it's not true for everyone.

I personally witnessed a family member experience psychosis from repeated, regular 'pot' use and once the weed smoking stopped, so did the hospitalizations. It's been nearly 30 years of relative peace since my family member stopped smoking pot. This person continues to take medication for bipolar/schizoaffective disorder but has not gone off the rails. At one time she was diagnosed with paranoid schizophrenia, including homicidal tendencies.

That said, I am not suggesting that smoking or ingesting cannabis played a role in what happened to Rob Reiner - but it may have. I also believe that as THC is legalized, we'll have more data/better data in the long run.

17 replies = new reply since forum marked as read
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More Than Just a High: The Cannabis-Schizophrenia Link - YALE School of Medicine (Original Post) mzmolly Dec 21 OP
I'm a living example of this... appmanga Dec 21 #1
Is this why alcohol use cannot be compared to cannabis use? efhmc Dec 21 #2
Both are potentially adverse to those who mzmolly Dec 21 #4
Thanks for the info. efhmc Dec 21 #9
I think alcohol is far worse than weed... appmanga Dec 21 #6
Thanks for sharing. mzmolly Dec 21 #3
Oh no. BannonsLiver Dec 21 #5
Yes, it can be harmful The Revolution Dec 21 #7
It isn't "reefer madness" to point out the marijuana of today isn't like the 1960s, valleyrogue Dec 21 #8
Depends what is added to the base cannabis. The flower alone is travelingthrulife Dec 21 #10
I agree. mzmolly Dec 21 #11
The biggest risk for developing schizophrenia is family history not pot Blues Heron Dec 21 #12
The biggest risk factor for developing "cannabis-induced psychosis" mzmolly Dec 21 #14
A danger to pot use 50 years ago that did this Captain Zero Dec 21 #13
I think it was PCP? mzmolly Dec 21 #15
I think I had the same experience drmeow Dec 21 #16
Yeah, hallucinogenics mzmolly Dec 21 #17

appmanga

(1,380 posts)
1. I'm a living example of this...
Sun Dec 21, 2025, 12:54 PM
Dec 21

...I have loads of family members who use weed without any severe issues, except for a brother who has the stomach pain that's recently been linked to marijuana usage, but it makes me paranoid and puts me into a bad mental state. So, I don't use it. I don't understand why someone would continue to use the drug if it negatively affects you, but some people do.

mzmolly

(52,609 posts)
4. Both are potentially adverse to those who
Sun Dec 21, 2025, 01:26 PM
Dec 21

Last edited Sun Dec 21, 2025, 02:17 PM - Edit history (1)

engage.

I drink wine weekly but moderate, don't drive etc. and haven't had an issue overall. That said, I think potential outcomes associated with alcohol use are widely acknowledged and accepted.

appmanga

(1,380 posts)
6. I think alcohol is far worse than weed...
Sun Dec 21, 2025, 01:28 PM
Dec 21

...and there are people exhibit personality changes after a few drinks that often affect others. In my experience, it takes a longer term of use of marijuana to get to the point where you feel others around are a "danger" to you.

mzmolly

(52,609 posts)
3. Thanks for sharing.
Sun Dec 21, 2025, 01:23 PM
Dec 21

I had an issue early on, and stopped smoking weed at about 14. I started young. I've also had a niece who had a psychotic break (hospitalization) due to use, she's still smoking or vaping it regularily. That, I don't get.

The Revolution

(880 posts)
7. Yes, it can be harmful
Sun Dec 21, 2025, 01:41 PM
Dec 21

While not as bad as other drugs certainly, and probably less destructive than even alcohol, weed can cause serious problems, especially when used in excess. This includes social problems if you let it take over your life. And it can be addicting. I have a family member that struggles to go an hour without a hit.

valleyrogue

(2,567 posts)
8. It isn't "reefer madness" to point out the marijuana of today isn't like the 1960s,
Sun Dec 21, 2025, 02:04 PM
Dec 21

which were generally pretty diluted in terms of the THC. THC levels are way higher now (no pun intended), and the significant health risks as a result of those levels shouldn't be shrugged off.

travelingthrulife

(4,463 posts)
10. Depends what is added to the base cannabis. The flower alone is
Sun Dec 21, 2025, 02:13 PM
Dec 21

pretty much the same as always.

Young people use cannabis, young people also get diagnosed with schizophrenia. Lots of weeds to wade through.

They are, so far, comparing apples to oranges in cannabis research. It is so far behind due to classification.

Start with flower alone and measure effects of burning vs vaporizing vs oral consumption. Then add the other products that have additives and exam that effect, one by one.

mzmolly

(52,609 posts)
11. I agree.
Sun Dec 21, 2025, 02:22 PM
Dec 21

I think as a result of the concentration of THC in various products, we'll see more adverse outcomes associated with its use.

My relative smoked all day nearly every day for a time. I'm sure that added to the outcomes in her case.

Blues Heron

(8,333 posts)
12. The biggest risk for developing schizophrenia is family history not pot
Sun Dec 21, 2025, 06:39 PM
Dec 21

From the article

The biggest risk factor for cannabis-induced psychosis and schizophrenia is a family history of schizophrenia, suggesting a genetic predisposition. For those with a family member diagnosed with schizophrenia, using cannabis is a high-risk gamble.

Caveat emptor - weed is not for everyone! But if it is, blaze away now that it’s schedule 3!

mzmolly

(52,609 posts)
14. The biggest risk factor for developing "cannabis-induced psychosis"
Sun Dec 21, 2025, 06:57 PM
Dec 21

is family history. However, if there is no family history of cannabis use, there may be no way to know in advance who is at risk.

For those with a family member diagnosed with schizophrenia, using cannabis is a high-risk gamble. Even without a family history, waiting until age 25 before using is recommended, as brain development continues into young adulthood (7,8).

Captain Zero

(8,736 posts)
13. A danger to pot use 50 years ago that did this
Sun Dec 21, 2025, 06:57 PM
Dec 21

Was dealers sprinkling veterinary surgical medicine, I forget the name of it, Into the bags of pot. At least where I lived it happened. Pot treated that way would make some people paranoid. Now it may have been hearsay, but that was at that time an argument for legalization to make sure marijuana was pure.

mzmolly

(52,609 posts)
15. I think it was PCP?
Sun Dec 21, 2025, 07:03 PM
Dec 21

I believe I have experienced the 'joys' of PCP, without prior knowledge.

I am supportive of legalization for the reasons you note, and because as it can bring more knowledge and appropriate regulation.

drmeow

(5,920 posts)
16. I think I had the same experience
Sun Dec 21, 2025, 07:55 PM
Dec 21

didn't put me off pot but definitely put me off hallucinogenics - as a result, I was the babysitter when my friends did shrooms!

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