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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsMore Than Just a High: The Cannabis-Schizophrenia Link - YALE School of Medicine
Beyond the high associated with marijuana, many users report paranoia or hallucinations while under the influence. This is due to the active component, Tetrahydrocannabinol (THC). THC binds to receptors in the brain and triggers a series of reactions in brain cells. Typically, these effects fade after the high wears off, but in some cases, they may last longer, leading to whats known as cannabis-induced psychosis.
In high-risk individuals, cannabis can disrupt brain development and lead to conditions like schizophreniaa severe mental illness characterized by long-term hallucinations, delusions, and paranoia. A Finnish study of 18,000 individuals with cannabis-induced psychosis found that nearly 50% were later diagnosed with schizophrenia (1). Other studies confirm that regular use, especially of high-potency products, increases the risk of developing schizophrenia by four times (2). This risk is comparable to the relationship between high cholesterol and heart disease.
The Specialized Treatment Early in Psychosis (STEP) program at Yale found that over 75% of patients with early schizophrenia had a history of cannabis use, further cementing this link (3).
More at: YALE School of Medicine
I'm sharing this as a caution, in part due to the tragedy of Rob Reiner. His son was of the impression that he could be 'California sober' and continue to use weed, without any ill effects. While this may be true for most, it's not true for everyone.
I personally witnessed a family member experience psychosis from repeated, regular 'pot' use and once the weed smoking stopped, so did the hospitalizations. It's been nearly 30 years of relative peace since my family member stopped smoking pot. This person continues to take medication for bipolar/schizoaffective disorder but has not gone off the rails. At one time she was diagnosed with paranoid schizophrenia, including homicidal tendencies.
That said, I am not suggesting that smoking or ingesting cannabis played a role in what happened to Rob Reiner - but it may have. I also believe that as THC is legalized, we'll have more data/better data in the long run.
appmanga
(1,380 posts)...I have loads of family members who use weed without any severe issues, except for a brother who has the stomach pain that's recently been linked to marijuana usage, but it makes me paranoid and puts me into a bad mental state. So, I don't use it. I don't understand why someone would continue to use the drug if it negatively affects you, but some people do.
efhmc
(16,077 posts)mzmolly
(52,609 posts)Last edited Sun Dec 21, 2025, 02:17 PM - Edit history (1)
engage.
I drink wine weekly but moderate, don't drive etc. and haven't had an issue overall. That said, I think potential outcomes associated with alcohol use are widely acknowledged and accepted.
efhmc
(16,077 posts)appmanga
(1,380 posts)...and there are people exhibit personality changes after a few drinks that often affect others. In my experience, it takes a longer term of use of marijuana to get to the point where you feel others around are a "danger" to you.
mzmolly
(52,609 posts)I had an issue early on, and stopped smoking weed at about 14. I started young.
I've also had a niece who had a psychotic break (hospitalization) due to use, she's still smoking or vaping it regularily. That, I don't get.
BannonsLiver
(20,256 posts)
The Revolution
(880 posts)While not as bad as other drugs certainly, and probably less destructive than even alcohol, weed can cause serious problems, especially when used in excess. This includes social problems if you let it take over your life. And it can be addicting. I have a family member that struggles to go an hour without a hit.
valleyrogue
(2,567 posts)which were generally pretty diluted in terms of the THC. THC levels are way higher now (no pun intended), and the significant health risks as a result of those levels shouldn't be shrugged off.
travelingthrulife
(4,463 posts)pretty much the same as always.
Young people use cannabis, young people also get diagnosed with schizophrenia. Lots of weeds to wade through.
They are, so far, comparing apples to oranges in cannabis research. It is so far behind due to classification.
Start with flower alone and measure effects of burning vs vaporizing vs oral consumption. Then add the other products that have additives and exam that effect, one by one.
mzmolly
(52,609 posts)I think as a result of the concentration of THC in various products, we'll see more adverse outcomes associated with its use.
My relative smoked all day nearly every day for a time. I'm sure that added to the outcomes in her case.
Blues Heron
(8,333 posts)From the article
The biggest risk factor for cannabis-induced psychosis and schizophrenia is a family history of schizophrenia, suggesting a genetic predisposition. For those with a family member diagnosed with schizophrenia, using cannabis is a high-risk gamble.
Caveat emptor - weed is not for everyone! But if it is, blaze away now that its schedule 3!
mzmolly
(52,609 posts)is family history. However, if there is no family history of cannabis use, there may be no way to know in advance who is at risk.
For those with a family member diagnosed with schizophrenia, using cannabis is a high-risk gamble. Even without a family history, waiting until age 25 before using is recommended, as brain development continues into young adulthood (7,8).
Captain Zero
(8,736 posts)Was dealers sprinkling veterinary surgical medicine, I forget the name of it, Into the bags of pot. At least where I lived it happened. Pot treated that way would make some people paranoid. Now it may have been hearsay, but that was at that time an argument for legalization to make sure marijuana was pure.
mzmolly
(52,609 posts)I believe I have experienced the 'joys' of PCP, without prior knowledge.
I am supportive of legalization for the reasons you note, and because as it can bring more knowledge and appropriate regulation.
drmeow
(5,920 posts)didn't put me off pot but definitely put me off hallucinogenics - as a result, I was the babysitter when my friends did shrooms!
mzmolly
(52,609 posts)and I don't get along.