I actually had a lot of trouble staffing up a few years ago and the situation has only gotten worse. (which is better in real world terms for job hunters)

That being said housing and rentals are out of control and rising a lot faster than wages. I expect finding a place to live will be harder than finding a job.

The city's traffic infrastructure is also being pressed by all the recent transplants, so that sucks a lot.

and could use the extra votes.

Make sure you check out Boulder too, lots of non profits there.

No better place to live. Denver, it's beautiful mountains and liberal people are still here but most areas are not affordable unless you make a very good salary. Lots of people live in the less expensive areas around Denver (not Boulder or Douglas County) and commute in. It's not NY yet but has grown in so many ways, not all of them good. (Like sitting for hours trying to get to the ski areas.) There are still many outstanding non-profits but not easy to get these jobs and our great public service jobs (NOAA, NIST, CU etc) are all being cut. More and more jobs are not offering important medical and vacation benefits.
You might want to check out Ft. Collins too; it's a pleasant town, not so expensive and easy to get to the mountains.
You will never regret moving to CO and you will never have enough time to see all its beauty. If you can afford it.