2022 US Senate Election cycle is more favorable to Democrats than in 2020.

In 2020- Democratic held US Senate seats up are:
Safe Democratic
RI- Reed-D
MA- Markey-D
NJ- Booker-D
DE- Coons-D
OR- Merkley-D
IL- Durbin-D
Likely/Safe Democratic
VA- Warner-D
NM- OPEN Udall/Lujan-D
Likely Democratic
MN- Smith-D
Lean/Likely Democratic
MI- Peters-D
Lean Democratic
NH- Shaheen-D
Tilt/Lean Republican.
AL- Jones-D.
In 2020 Democratic held US Senate seats up are
Safe Democratic
CA- Harris-D
HI- Schatz-D
NY- Schumer-D
CT- Blumenthal-D
VT- Leahy-D
MD- Van Hollen-D
OR- Wyden-D
IL- Duckworth-D
Likely/Safe Democratic
WA- Murray-D
Likely Democratic
CO- Bennet-D
Lean/Likely Democratic
NV- Cortez Masto-D
Lean Democratic
NH- Hassan-D
Tilt/Lean Democratic
AZ- Kelly-D. If he wins in 2020.
Republican held US Senate seats Democrats are likely to pick up in 2020
AZ- McSally-R vs Kelly-D
CO- Gardner-R
GA- Perdue-R
IA- Ernst-R
ME- Collins-R
NC- Tillis-R
TX- Cornyn-R vs Joaquin Castro-D with Beto O'Rourke-D on the 2020 Democratic Ticket.
Republican held US Senate seats Democrats are likely to pick up in 2022.
AZ- McSally-R(if Stanton-D is the Democratic nominee/Gallego-D runs for AZ Governor to suceed term limited Ducey-R).
FL- Rubio-R(if Gillum-D or Graham-D is the Democratic nominee).
GA- Isakson-R(if Abrams-D or Tomlinson-D is the Democratic nominee.)
IA- Grassley-R(Finkenauer-D/Axne-D defeats Ernst-R in 2020).
NC- Burr-R(Cooper-D is the Democratic nominee.)
OH- Portman-R(Cordray-D or Ryan-D are the Democratic nominee).
PA- Toomey-R(Lamb-D is the Democratic nominee.)
WI- Johnson-R(Pocan-D is the Democratic nominee.)