2022 is likely to be the year Democrats regain control of the US Senate.

2020- Democrats need a net gain of 4 seats assuming Trump/Pence steal the election again.
Democrats will hold onto DE(Coons-D), IL(Durbin-D), MA(Markey-D/Kennedy-D), MI(Peters-D), MN(Smith-D), NH(Shaheen-D), NJ(Booker-D), NM(OPEN Udall-D/Lujan-D), OR(Merkley-D), RI(Reed-D) and VA(Warner-D) but lose AL(Jones-D/Tuberville-R). -1D
Republicans will hold onto AK(Sullivan-R), AR(Cotton-R), both GA seats(David and Sonny Perdue-R), ID(Risch-R), IA(Ernst-R), KS(OPEN Roberts-R/Marshall-R), KY(McConnell-R), LA(Cassidy-R), MS(Hyde Smith-R), MT(Daines-R), NE(Sasse-R), OK(Inhofe-R/Pruitt-R), SC(Graham-R), SD(Rounds-R), TN(OPEN Alexander-R/Hagerty-R), TX(Cornyn-R), WV(Moore Capito-R), and WY(OPEN Enzi-R/Lummis-R) but lose AZ(McSally-R/Kelly-D) and CO(Gardner-R/Hickenlooper-D).
Republicans could lose ME(Collins-R) if ME Democrats can convince ME Independent voters that a vote for Collins-R is a vote for Moscow Mitch McConnell as Senate Majority Leader. and NC(Tillis-R), if Governor Roy Cooper-D has coattails for the Democratic nominee for the US Senate.
Democrats will have a net gain of 3 seats. Pence-R or the Democratic VP will break the tie vote.
2022-
Democrats will hold onto
HI(Schatz-D)
NY(Schumer-D)
CT(Blumenthal-D)
VT(Leahy-D)
MD(Van Hollen-D)
CA(Harris-D)
OR(Wyden-D)
WA(Murray-D)
IL(Duckworth-D)
CO(Bennet-D)
NV(Cortez Masto-D)
NH(Hassan-D)
AZ(Kelly-D)
Every Democratic held US Senate seat up in 2022 will stay in the Democratic column.
Republicans will hold onto
AL(OPEN Shelby-R)
AK(Murkowski-R)
AR(Boozman-R)
ID(Crapo-R)
IN(Young-R)
KS(Moran-R)
KY(Paul-R)
LA(Kennedy-R)
MO(Blunt-R)
ND(Hoeven-R)
OH(Portman-R)
OK(Lankford-R)
SC(Scott-R)
SD(Thune-R)
UT(Lee-R).
Republican held US Senate seats that can go Democratic.
FL(Rubio-R) Democratic wave and Top Tier Democratic Nominee. (Castor-D, Crist-D, Fried-D, Graham-D, or Gillum-D).
GA(Perdue-R) Democratic wave and Top Tier Democratic Nominee. (McBath-D)
IA(OPEN Grassley-R) Democratic wave and Too Tier Democratic Nominee. (Axne-D, Finkenaur-D, or Sand-D).
NC(OPEN Burr-R) If Cooper-D runs.
PA(Toomey-R) The female US House Members from the Philly metro area( Dean-D, Scanlon-D, Houlahan-D, or Wild-D)
WI(Johnson-R) (Pocan-D or Kind-D).
NC, PA, and WI will be the Republican held US Senate seats up in 2022 Democrats will pick up. Democrats will have a net gain of 3 seats. 53D 47R.
2024
Democrats will hold onto
HI(Hirono-D)
VT(Sanders-I/D)
MD(Cardin-D)
NY(Gillibrand-D)
ME(King-I/D)
MA(Warren-D/Kennedy-D/Moulton-D/Pressley-D)
MN(Klobuchar-D)
NM(Heinrich-D)
RI(Whitehouse-D)
DE(Carper-D)
CT(Murphy-D)
WA(Cantwell-D)
VA(Kaine-D)
PA(Casey-D)
NJ(Menendez-D)
WI(Baldwin-D)
CA(OPEN Feinstein-D)
OH(Brown-D)
MI(Stabenow-D)
NV(Rosen-D)
MT(Tester-D)
WV(Manchin-D)
AZ(Sinema-D)

Manchin(D-WV) is highly vulnerable if Governor Justice(R-WV) runs.

Republicans will hold onto
WY(Barraso-R)
UT(Romney-R)
NE(Fischer-R)
MS(Wicker-R)
ND(Cramer-R)
TN(Blackburn-R)
IN(Braun-R)
MO(Hawley-R)

Republican held US Senate seats up in 2024 that can go Democratic.
FL(Scott-R) if US Reps. (Murphy-D, Soto-D, Demings-D, Castor-D, Deutch-D, Wasserman Schultz-D, or Mucarsel Powell-D ) run.
TX(Cruz-R) If US Reps. (Fletcher-D, Gonzalez-D, Escobar-D, Castro-D, Allred-D, Veasey-D, or Vela-D) run.