2022 US Senate Election cycle is more Democratic friendly than the 2020 US Senate Election cycle.

In 2020
D to R
AL(Jones-D) if Moore-R and Mooney-R does not win the 2020 Republican nomination.
MI(Peters-D)James-R(if Democrats lose the 2020 US Presidential Election in MI.)
Democrats hold onto
DE(Coons-D)
IL(Durbin-D)
MA(Markey-D)
MI(Peters-D) if Democrats win the 2020 US Presidential Election in MI.
MN(Smith-D)
NH(Shaheen-D)
NJ(Booker-D)
NM(OPEN Udall-D)Lujan-D
OR(Merkley-D)
RI(Reed-D)
VA(Warner-D)
Democrats will lose 1 or 2 seats.
Democrats need to win 6 Republican held US Senate seats to secure a majority in the US Senate in 2020.
AZ special(McSally-R)Kelly-D
CO(Gardner-R)Hickenlooper-D
GA regular(Perdue-R)Tomlinson-D
IA(Ernst-R)Greenfield-D
ME(Collins-R)Gideon-D
NC(Tillis-R)Cunningham-D
Democrats are more likely to win AZ,CO,ME and NC..
2022 if a Democrat is in the White House.
Most vulnerable Democratic held US Senate seats are.
AZ(Kelly-D) if and only if Ducey-R is the Republican Nominee.
NV(Cortez Masto-D) if and only if Amodei-R is the Republican Nominee.
NH(Hassan-D) if Sununu-R or Ayotte-R run.
Democrats will hold on to
CA(Harris-D)
CO(Bennet-D) if Bennet-D retires(Griswold-D or Neguse-D)
CT(Blumenthal-D) if Blumenthal-D retires(Himes-D or Hayes-D)
HI(Schatz-D)
IL(Duckworth-D)
MD(Van Hollen-D)
NY(Schumer-D) if Schumer-D retires(Ocasio Cortez-D or Suozzi-D )
OR(Wyden-D) if Wyden-D retires(Brown-D or Read-D)
VT(Leahy-D) if Leahy-D retires(Zuckerman-D or Donovan-D)
WA(Murray-D) if Murray-D retires(Delbene-D, Jayapal-D or Schrier-D)
Democrats need to win 4 Republican held US Senate seats in 2022 to secure a majority in 2022.
PA(Toomey-R) Fetterman-D
WI(OPEN Johnson-R) Kind-D, Pocan-D, Kaul-D, or Barnes-D.
NC(OPEN Burr-R) Jackson-D or Martin-D
GA(Loeffler-R) Tomlinson-D
FL(Rubio-R) Graham-D
IA(OPEN Grassley-R) Finkenauer-D or Axne-D