Democrats will easily end up with 53 US Senate seats after 2022.

36 Democratic US Senators not up for re-election in 2022.
14 Democratic US Senators up for re-election in 2022. All 14 of them including VT(OPEN Leahy-D/Welch-D) will win re-election.
37)VT(Welch-D)
38)CA(Padilla-D)
39)NY(Schumer-D)
40)HI(Schatz-D)
41)MD(Van Hollen-D)
42)IL(Duckworth-D)
43)OR(Wyden-D)
44)CT(Blumenthal-D)
45)CO(Bennet-D)
46)WA(Murray-D)
47)AZ(Kelly-D)
48)NH(Hassan-D)
49)NV(Cortez Masto-D)
50)GA(Warnock-D)
Democrats will win 3 Republican held US Senate seats up in 2022.
51)PA(OPEN Toomey-R/Fetterman-D vs Oz-R)
52)OH(OPEN Portman-R/Ryan-D vs Vance-R)
53)WI(Johnson-R vs Barnes-D)

NC(OPEN Burr-R/Budd-R vs Beasley-D) and FL(Rubio-R vs Demings-D) are likely to go either way.