There are 4 Republican held US Senate seats up for re-election in 2022 that the Democrats will win.

1)PA(OPEN Toomey-R) will go to Fetterman-D.
2)WI(Johnson-R) will go to Barnes-D. Barnes is a better campaigner than Feingold. Barnes is not going to take a risk like not taking soft money contributions which was in the McCain/Feingold bill.
3)NC(OPEN Burr-R) will go to Beasley-D. Polls have Beasley in a statistical tie race against all of the Republican candidates.
4)OH(OPEN Portman-R) will go to Ryan-D. Polls have Ryan in a statistical tie race against all of the Republican candidates.
On the Democratic side, GA could be the seat. The winner of this seat will be decided on 1/2023. The race is a pure Tossup.
Democrats will hold onto NV,AZ,NH,and CO.

Democrats will win
37)NY(Schumer-D)
38)HI(Schatz-D)
39)CA(Padilla-D)
40)VT(Welch-D)
41)MD(Van Hollen-D)
42)CT(Blumenthal-D)
43)OR(Wyden-D)
44)IL(Duckworth-D)
45)WA(Murray-D)
46)CO(Bennet-D)
47)NH(Hassan-D)
48)AZ(Kelly-D)
49)NV(Cortez Masto-D)
50)PA(Fetterman-D)
51)WI(Barnes-D)
52)NC(Beasley-D)