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safeinOhio

(33,925 posts)
Thu Aug 13, 2020, 05:31 AM Aug 2020

Why some don't get COVID-19 or have mild symptoms.

https://science.sciencemag.org/content/early/2020/08/04/science.abd3871


Abstract
Many unknowns exist about human immune responses to the SARS-CoV-2 virus. SARS-CoV-2 reactive CD4+ T cells have been reported in unexposed individuals, suggesting pre-existing cross-reactive T cell memory in 20-50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4+ T cell repertoire. We demonstrate a range of pre-existing memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63, or HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in COVID-19 disease.
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Why some don't get COVID-19 or have mild symptoms. (Original Post) safeinOhio Aug 2020 OP
I have a graduate degree and I can't understand a bit of this. n/t phylny Aug 2020 #1
My guess: Some people have T-Cells that can help them fend off this coronavirus because Baitball Blogger Aug 2020 #2
Thank you! phylny Aug 2020 #3
At the conclusion of the paper, the writers say that there is evidence that previous Nay Aug 2020 #4
I brought it up because safeinOhio Aug 2020 #5
I think it's probably true, but researchers haven't found the exact pathway that Nay Aug 2020 #6
Message auto-removed Name removed Aug 2020 #7
Thank you. safeinOhio Aug 2020 #8
Thanks clarkd101 Aug 2020 #9
You are welcome and welcome to DU. safeinOhio Aug 2020 #10

Baitball Blogger

(47,722 posts)
2. My guess: Some people have T-Cells that can help them fend off this coronavirus because
Thu Aug 13, 2020, 09:34 AM
Aug 2020

of previous exposure to common colds. But, no one knows why or where they got that exposure.

Nay

(12,051 posts)
4. At the conclusion of the paper, the writers say that there is evidence that previous
Thu Aug 13, 2020, 10:12 AM
Aug 2020

exposure to certain specific cold viruses can stimulate a person's T-cells (cells that will 'remember' invading viruses and prompt a very quick bodily reaction to stop the invader) quickly enough that the person will have an asymptomatic response to COVID19 -- IOW, the virus gets beaten back before you get sick -- or the person will have only mild symptoms and then shake off the virus. They conclude by saying their results are still very speculative.

But I may be reading this incorrectly, so it's IMHO.

Nay

(12,051 posts)
6. I think it's probably true, but researchers haven't found the exact pathway that
Thu Aug 13, 2020, 12:28 PM
Aug 2020

goes from "existing cold germ immunity" to "T-cells that attack COVID too." If they can find out exactly what is happening in all those steps, there's a good chance that they'll be able to develop a vaccine or shot that will at least keep a case of COVID from killing you or damaging you severely. Let's hope!

Response to safeinOhio (Original post)

safeinOhio

(33,925 posts)
8. Thank you.
Wed Aug 26, 2020, 05:35 PM
Aug 2020

Trying to keep up. I now wear a shield along with a mask. Looking more like aerosol spray may be more dangerous than any other way of spreading the virus. That along with load and speed has me trying that combination to stay safe. Cant hurt.

safeinOhio

(33,925 posts)
10. You are welcome and welcome to DU.
Sat Aug 29, 2020, 11:27 AM
Aug 2020

Best place on the internet for info. If you find something good, be sure to share it here.

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