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NJCher

(38,479 posts)
Sun Apr 16, 2023, 07:09 PM Apr 2023

MIT Researchers Make Discovery That Could Lead To The Reversal Of Alzheimer's Disease

Story by David Wetzel • 14h ago

snip

Neuroscientists at MIT have discovered a way to potentially reverse neurodegeneration and other issues related to Alzheimer's disease, according to a news release from the school.

Researchers, experimenting on mice, found that interfering with an enzyme that is typically overactive in the brains of people with Alzheimer's can reverse the degeneration in the brain.


The neuroscientists treated the mice with a peptide that successfully blocked the hyperactive version of enzyme CDK5 and found that it resulted in heavy reductions in the neurodegeneration and DNA damage taking place inside the brain. The experiment resulted in those mice improving in their ability to perform tasks such as navigating a water maze.

“We found that the effect of this peptide is just remarkable,” says Li-Huei Tsai, director of MIT’s Picower Institute for Learning and Memory and the senior author of the study. “We saw wonderful effects in terms of reducing neurodegeneration and neuroinflammatory responses, and even rescuing behavior deficits.”

snip

More at link. Knewz.

Link to story at MIT website.

19 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
MIT Researchers Make Discovery That Could Lead To The Reversal Of Alzheimer's Disease (Original Post) NJCher Apr 2023 OP
K&R n/t ms liberty Apr 2023 #1
My grandmother had very bad early onset Alzheimer's Walleye Apr 2023 #2
Let's hope for rapid progress. Sure sounds promising Raven123 Apr 2023 #3
Excellent news Joinfortmill Apr 2023 #4
That discovery could change so many lives in a good way. rubbersole Apr 2023 #5
that sounds very promising ... stopdiggin Apr 2023 #6
Yes, fantastic news. JudyM Apr 2023 #16
Let's hope that this discovery will lead to a cure for Alzheimer's. blue neen Apr 2023 #7
That would be a real dream come true for so many families! calimary Apr 2023 #14
MmmHmm... Cellular Peptide Cake with Mint Frosting! Video TeamProg Apr 2023 #8
This is the best news I have heard in forever!!! nt Laura PourMeADrink Apr 2023 #9
Me too! MLAA Apr 2023 #10
Great news. It got me thinking.....if the world could focus its resources on medical Ziggysmom Apr 2023 #11
Great news, even more so because it could be reversed vs. merely stopped. Abolishinist Apr 2023 #12
After umpteen gazillion rosy discoveries/forecasts like this, I'll wait for the results. keithbvadu2 Apr 2023 #13
That's your own psychological issue NJCher Apr 2023 #17
Exactly! Totally with you! Laura PourMeADrink Apr 2023 #19
This is great news! I never thought the amyloid plaque Phoenix61 Apr 2023 #15
Good news. Hopefully it will be affordable. live love laugh Apr 2023 #18

Walleye

(37,016 posts)
2. My grandmother had very bad early onset Alzheimer's
Sun Apr 16, 2023, 07:25 PM
Apr 2023

They didn’t even have a name for it back then, it was very difficult for my parents. I’m hopeful for this treatment

rubbersole

(8,847 posts)
5. That discovery could change so many lives in a good way.
Sun Apr 16, 2023, 08:28 PM
Apr 2023

Not only the patients, but their loved ones. Memory care facilities will always be needed. The people who work in them are angels.

stopdiggin

(13,173 posts)
6. that sounds very promising ...
Sun Apr 16, 2023, 08:29 PM
Apr 2023

almost afraid to get my hopes up
(I've heard of almost nothing prior to this that actually talks about some 'reversal')

blue neen

(12,439 posts)
7. Let's hope that this discovery will lead to a cure for Alzheimer's.
Sun Apr 16, 2023, 08:54 PM
Apr 2023

It's so sorely needed.

calimary

(84,942 posts)
14. That would be a real dream come true for so many families!
Sun Apr 16, 2023, 10:20 PM
Apr 2023

Getting Grandma/Grandpa Back!

Even just the thought of it can be a real mood-lifter.

Ziggysmom

(3,681 posts)
11. Great news. It got me thinking.....if the world could focus its resources on medical
Sun Apr 16, 2023, 09:43 PM
Apr 2023

and scientific research instead of weapons and war, what a great world this could be.

Abolishinist

(2,119 posts)
12. Great news, even more so because it could be reversed vs. merely stopped.
Sun Apr 16, 2023, 09:55 PM
Apr 2023

Here's an idea... what if we worked on turning people into mice, as they seem to be at the forefront of medical technology.

keithbvadu2

(40,908 posts)
13. After umpteen gazillion rosy discoveries/forecasts like this, I'll wait for the results.
Sun Apr 16, 2023, 10:10 PM
Apr 2023

I like the encouragement and possibilities but, many times, we have built up great expectations too early.

When it works itself out, all the better.
---------------------------------------------------

Example::: Many cures/treatments for COVID

Some by science, some by faith/wishful thinking/contrarianism.

https://democraticunderground.com/100215874832

NJCher

(38,479 posts)
17. That's your own psychological issue
Mon Apr 17, 2023, 05:45 AM
Apr 2023

Why do you want me or anyone else to know about it?

Phoenix61

(17,781 posts)
15. This is great news! I never thought the amyloid plaque
Sun Apr 16, 2023, 10:34 PM
Apr 2023

path was where they were going to find a treatment and/or cure for Alzheimer’s.

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