Yay science!

IF it works … hopefully they will take the Jonas Salk approach and make it available for humanity and not profit .

Imagine Covid eradicated forever 🤔



✌🏻

If republicons are in charge, that will never happen.

All the disease we've eradicated, and I'll never understand why they held the door open for this one.

They held the door open because COVID creates a generalized fear and chaos, and another niche for the Culture Wars. It also feeds on the anti intellectualism in this country. A frightened populace tends to vote more conservatively. And in chaos there is profit to be made more easily. Also in chaos there is less confidence in government solving our problems. So it fed their anti government meme as well. A win, win, win for them and a lose, lose, lose for the rest of us.
They were CREATING THEIR OWN REALITY!!!! And they used that reality to their great benefit. Think $$$$$ loads of government money being given to private hands with no oversight.

The Spanish Flu had a crude mortality rate (ie percent of the world population that died) of 2.7%. COVID up to now has been one ninth of that, at 0.3%. While that represents millions of needless deaths and tragically ruined lives, it was still small enough that Republicans (and conservatives elsewhere) could use it for manipulation. Too many people dying and Republican voters / Fox News viewers would eventually catch on that for instance, everyone in church (ie, members of their local in-group) was dying. But at 0.3% crude mortality rate, only a large handful died; enough to be dismissed through cognitive dissonance &/or manipulation via media and authority. God moves in mysterious ways, to continue and close that one narrow example.

They knew what they had, and took full advantage of it. Not just to gain control over half the country but also to enable massive amounts of grift not only for themselves, but also for their favorite large scale investors, oligarchs, and so on.

The admin can and should easily do a special order nationalizing production and distribution to prevent future outbreaks and devastating emergency states. Even if the companies don’t pad their wallets or bonuses it will provide jobs and a huge boost to morale. Also bodes well for other coronaviruses like the cold and HIV etc.

No cure should cost the inflicted.

Let’s remember what it is: in this case it’s liquid with injectable reprogrammed carbon chains.

The only non-imaginary costs to civilization is supply chain maintenance ensuring materials/manufacturing/storage+delivery mechanism/distribution, plus the labor of the people working the jobs on that chain

I guess it will be a while before we find out if this is the breakthrough it sounds like and even longer before it becomes widely available. But what a ray of hope!

Let’s hope it is safe as well as effective.

from this new discovery.

Or an "antibody" they give you after Covid is present to kill it.

This is extremely preliminary and there's zero evidence it is anything beyond a hope in human studies so far. Still, it's interesting. Just don't expect much until much later in the studies. This is purely a preliminary study.

It may pan out and be a thing, or it may be another, "almost" moment. Both bring us closer to a better management.

So directly applying antibodies shouldn't be different.

The question is does the presence of antibodies cause the body to make more of those antibodies without the viral stimulus.

Create the antibody.

"Initially, the scientists integrated two human gene segments into the mice. This action stimulated the rodents' immune cells to rapidly synthesize a broad array of antibodies, akin to the ones our bodies could potentially create.

Subsequently, the group exposed the mice to the SARS-CoV-2 spike protein, the primary protein that our antibodies and existing vaccines aim at, derived from the initial Wuhan-Hu-1 coronavirus variant.

As a reaction, the mice generated nine distinct groups of antibodies that attached themselves to the spike protein."

One of those antibodies bines to a part of the virus not known to mutate. So, I suspect they will have to get our bodies to produce that antibody.

"Should these discoveries be successfully duplicated in humans, these antibodies might pave the way for improved COVID-19 vaccines and therapies."

If so, it may end up being a true breakthrough down the road.

The novel antibody, SP1-77, binds to the covid spike protein at a site which has SO FAR not mutated in any variant:
“SP1-77 binds the spike protein at a site that so far has not been mutated in any variant, and it neutralizes these variants by a novel mechanism,”
The article doesn't describe the novel mechanism.

The first thing that occurs to me is that the targeted site on the spike protein has not yet mutated because it has not yet received selection pressure.

Evolution proceeds by selection pressure. If there is no pressure to mutate and no advantage to mutating, then there is no advantage to transmitting a mutation, so there is no change. In other words, there has been no reason so far for that site on the spike protein to mutate and transmit the mutation to succeeding generations. Once that site on the spike protein is targeted by SP1-77, it will receive selection pressure and there will be an advantage for mutations of the site. Then we'll have a variant resistant to SP1-77.

That "novel mechanism" might demolish this argument, but the article doesn't describe it.It does say that this antibody interferes with the ability of covid to fuse the virus membrane with the cell membrane, which I think is different from previous antibodies.

This antibody could, though, give broad protection against all existing strains, so that's good.

edit: I somehow missed the references given by xocetacean in post #10 (sorry, and thanks!). The science.org link gives overwhelming detail, along with really beautiful color 3D visualizations of the proteins and their interactions.

Until they are on deaths doorstep. Then they will expect to be first in line, and refuse to acknowledge it saved their lives afterwards.

What a relief it would be to get vaccinated with this.

PLEASE!!!

Last edited Wed Nov 15, 2023, 05:44 PM - Edit history (24)

especially since America's 70% fully vaccinated Covid rate brings herd immunity within our sights.

Epidemiology 101: Viruses survive by mutating; viruses fade into oblivion when they can no longer out-mutate either their naturally or medically made antibodies.

Thanks to epidemiology, any antibody can now eventually be medically made -- which is why polio, anthrax, smallpox, measles, more recently HIV, and most recently Ebola are pretty much the stuff that distant memories are made of.

Welcome to the beginning of the end, Covid.


Rocknation