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sl8

(16,245 posts)
Tue May 14, 2024, 04:44 PM May 2024

Oldest Known Human Viruses Discovered In 50,000-Year-Old Neanderthal Bones

https://www.iflscience.com/oldest-known-human-viruses-discovered-in-50000-year-old-neanderthal-bones-74203

Oldest Known Human Viruses Discovered In 50,000-Year-Old Neanderthal Bones

It might add weight to the theory that viruses contributed to the extinction of the species.

Author HOLLY LARGE
Jr Copy Editor & Staff Writer

Edited by Maddy Chapman

Did viruses play a role in the extinction of Neanderthals? That’s what researchers from the Federal University of São Paulo have been trying to figure out, and in doing so, ended up uncovering the oldest known human viruses in a set of Neanderthal bones from over 50,000 years ago.

To make this finding, the team combed through the raw DNA sequencing data of two sets of Neanderthal remains recovered from Chagyrskaya cave in Russia. Within those raw sequences, they were looking for the remnants of the genomes – the entirety of an organism’s genetic information – of three types of DNA viruses: adenovirus, herpesvirus, and papillomavirus.

And they found them – remnants of all three groups, in fact. This makes the viruses the oldest human viruses ever discovered, taking the title away from those found in 31,600-year-old Homo sapiens remains.

This, the authors suggest in a preprint that’s yet to be peer-reviewed, demonstrated that not only was it feasible to identify bits of viral genomes in archaeological samples, but that Neanderthals could’ve been afflicted with the same viruses that affect humans today.

[...]

[H/T: New Scientist]



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Link to New Scientist article (paywall):
https://www.newscientist.com/article/2430389-oldest-known-human-viruses-found-hidden-within-neanderthal-bones/

================

https://www.biorxiv.org/content/10.1101/2023.03.16.532919v3

(Full text available at link with no paywall)

Reconstructing prehistoric viral genomes from Neanderthal sequencing data

Renata C. Ferreira, Gustavo V. Alves, Marcello Ramon, Fernando Antoneli, Marcelo R. S. Briones

doi: https://doi.org/10.1101/2023.03.16.532919

This article is a preprint and has not been certified by peer review [what does this mean?].

Abstract

DNA viruses that produce persistent infections have been proposed as potential causes for the extinction of Neanderthals and therefore, the identification of viral genome remnants in Neanderthal sequencing reads is an initial step to address this hypothesis. Here, as proof of concept, we searched for viral remnants in sequencing reads of Neanderthal genome data by mapping to adenovirus, herpesvirus and papillomavirus, which are double stranded DNA viruses that may establish lifelong latency and can, produce persistent infections. The reconstructed ancient viral genomes of adenovirus, herpesvirus and papillomavirus revealed conserved segments, with nucleotide similarity to extant viral genomes, and variable regions in coding regions with substantial divergence to extant close relatives. Sequencing reads mapped to extant viral genomes showed deamination patterns of ancient DNA and that these ancient viral genomes showed divergence consistent with the age of these samples (≈50,000 years) and viral evolutionary rates (10−5 to 10−8 substitutions/site/year). Analysis of random effects shows that the Neanderthal mapping to genomes of extant persistent viruses is above the expected by random similarities of short reads. Also, negative control with a nonpersistent DNA virus does not yield statistically significant assemblies. This work demonstrates the feasibility of identifying viral genome remnants in archaeological samples with signal-to-noise assessment.

Competing Interest Statement

The authors have declared no competing interest.

[...]



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Oldest Known Human Viruses Discovered In 50,000-Year-Old Neanderthal Bones (Original Post) sl8 May 2024 OP
And the other future humans? Lovie777 May 2024 #1
Thanks for post. riversedge May 2024 #2
Sounds like the start of a Stephen King story. Scrivener7 May 2024 #3
You're quite welcome. sl8 May 2024 #4
Ooh. I didn't see it before. Thanks. Scrivener7 May 2024 #5
Interesting but it doesn't follow that the viruses were pathogens Warpy May 2024 #6

Lovie777

(15,009 posts)
1. And the other future humans?
Tue May 14, 2024, 05:09 PM
May 2024

As complex as many species are during millions or more or less years, attack from viruses is nature.

As humans evolved brain wise, so did the ability to find results to some of these.

Neandertals from discovery in history apparently believed in its environment where others ventured elsewhere in the world.

sl8

(16,245 posts)
4. You're quite welcome.
Tue May 14, 2024, 06:07 PM
May 2024

The full text is available at the link, with no paywall, if you're interested.

Warpy

(113,130 posts)
6. Interesting but it doesn't follow that the viruses were pathogens
Tue May 14, 2024, 11:40 PM
May 2024

or weren't introduced during the 50,000 years the bones sat in the dirt. I do wish them success in teasing out the genome, the structure (including spike proteins) and what the virus might do to living tissue, although they'd be hard pressed to get any Neanderthal living tissue and a lot of viruses are species specific.

I just think it unlikely anything they discover from 50,000 years ago could be considered a proximate cause of species extinction 14,000 years later. I think the culprit for that was the Camparnian Ignimbrite Event, something that devastated the Neandertal habitat
at the time, from the northeastern Mediterranean through central Europe and into parts of Siberia. The stragglers just lacked enough of a diverse DNA pool to survive much longer I doubt crossbreeding with modern humans was all that successful, although it did produce fertile offspring from time to time.

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