In 2010 Stephen Hawking, in The Grand Design, announced that philosophy was "dead" because it had "not kept up with modern developments in science, particularly physics". He was not referring to ethics, political theory or aesthetics. He meant metaphysics, the branch of philosophy that aspires to the most general understanding of nature – of space and time, the fundamental stuff of the world. If philosophers really wanted to make progress, they should abandon their armchairs and their subtle arguments, wise up to maths and listen to the physicists.

This view has significant support among philosophers in the English-speaking world. Bristol philosopher James Ladyman, who argues that metaphysics should be naturalised, and who describes the accusation of "scientism" as "badge of honour", is by no means an isolated case.

But there could not be a worse time for philosophers to surrender the baton of metaphysical inquiry to physicists. Fundamental physics is in a metaphysical mess and needs help. The attempt to reconcile its two big theories, general relativity and quantum mechanics, has stalled for nearly 40 years. Endeavours to unite them, such as string theory, are mathematically ingenious but incomprehensible even to many who work with them. This is well known. A better-kept secret is that at the heart of quantum mechanics is a disturbing paradox – the so-called measurement problem, arising ultimately out of the Uncertainty Principle – which apparently demonstrates that the very measurements that have established and confirmed quantum theory should be impossible. Oxford philosopher of physics David Wallace has argued that this threatens to make quantum mechanics incoherent which can be remedied only by vastly multiplying worlds.

Beyond these domestic problems there is the failure of physics to accommodate conscious beings. The attempt to fit consciousness into the material world, usually by identifying it with activity in the brain, has failed dismally, if only because there is no way of accounting for the fact that certain nerve impulses are supposed to be conscious (of themselves or of the world) while the overwhelming majority (physically essentially the same) are not. In short, physics does not allow for the strange fact that matter reveals itself to material objects (such as physicists).