ALERT: If you're using Malwarebytes, you might want to double-check your "updates" settings. [View all]
Two computers in our house had problems recently -- one resulted in MalWareBytes vanishing completely. Microsoft Security Essentials was also turned off, and couldn't be opened. I rebooted in Safe Mood, reinstalled MWB, scanned, and ran the ScanDisk utility in Windows. MWB's background updater seems to have been one of the files corrupted. Weirdly, MWB seemed to be able to find my account info (correctly listed the other computer as having MWB installed and didn't require a password), so not all the files were erased/corrupted.
The other Wintel box, which hardly ever connects to any Web sites, has not had any MWB updates in 30 days, which led to an alert. When I tried to check the settings, I needed to login with my MWB password, which I didn't have on hand. I don't remember MWB requiring an actual login previously.
All this makes me suspect some new MWB-targeting malware is out there, and may be having some success. Stay safe.
Post if you know anything more. (Well, anything relevant.)