Safari, FF, and Chrome are all built on the same engine now. Performance wise I don’t notice any difference. It may sound weird, but I usually have all three up at once at home.
I find it easier to use Chrome for accessing Google apps and Youtube. If I’m on the Internet with a different computer (usually a windows PC) and it has Chorome installed, or if I can install it, Chrome is nice. If I login to my Google account all my Google apps are available and the big one for me… my bookmarks follow me! yay. It also updates flash automatically so if there is a security update it should theoretically be good to go. Also, some sites I use I have extensions available for added features I use that are not available for Safari.
I find Safari easier on my eyes and prefer it for surfing at home. I’m also just a lot more used to it.
Firefox is decent too and is great when only 2 browsers just won’t do. 
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