And this study is a meta-analysis compiling other meta-analyses.
https://pubmed.ncbi.nlm.nih.gov/7950571/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868184/
https://absolutelymaybe.plos.org/2015/06/30/another-5-things-to-know-about-meta-analysis/
https://absolutelymaybe.plos.org/2014/01/20/5-key-things-to-know-about-meta-analysis/
https://www.researchgate.net/post/What_are_the_disadvantages_of_doing_a_meta-analysis
https://www.science.org/content/article/meta-analyses-were-supposed-end-scientific-debates-often-they-only-cause-more
As a retired mental health professional who has worked closely with psychiatrists, I found it both puzzling and frustrating that some people respond quite well to SSRI’s and others don’t. It can sometimes take several trials of various SSRI’s to find the right medication. Even then, some folks still struggle with depression that doesn’t respond to SSRI’s. A significant amount of research has shown that the combination of therapy and medication is far more effective at treating depression than either alone.
There is also a newer generation of depression medication, SNRI’s (serotonin-norepinephrine reuptake inhibtors) which have helped some folks.
= new reply since forum marked as read