Internally, there are lots of warnings about drug precautions.
What Do We Know About Safety?
Ashwagandha may be safe when taken in the short term (up to 3 months). There is not enough information to allow conclusions about its long-term safety to be reached.
In some individuals, ashwagandha preparations may cause drowsiness, stomach upset, diarrhea, and vomiting.
Although it is rare, there have been a number of cases that link liver injury to ashwagandha supplements.
Ashwagandha should be avoided during pregnancy and should not be used while breastfeeding.
Ashwagandha is not recommended for people who are about to have surgery, or for those who have autoimmune or thyroid disorders.
There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure, medicines that decrease the immune system response (immunosuppressants), sedatives, anti-seizure medications (anticonvulsants), and thyroid hormone medications.
Because ashwagandha may increase testosterone levels, people with hormone-sensitive prostate cancer should avoid its use.
https://www.nccih.nih.gov/health/ashwagandhaSide Effects of Ashwagandha
Side effects of ashwagandha may include diarrhea, headache, sedation, or nausea. Liver problems may occur.
Ashwagandha may increase testosterone levels.
Ashwagandha should not be used during pregnancy or breastfeeding.
Drug Interactions with Ashwagandha
Ashwagandha might lower blood sugar levels and thus make it unsafe to use with antihyperglycemic (glucose-lowering) medications (by lowering blood sugar too much).
Because of its potential to lower blood pressure, ashwagandha might not be safe in people who take medications to treat high blood pressure.
Ashwagandha, because it seems to make the immune system more active, could also interfere with medications that suppress the immune system. Examples of these medications include cyclosporine, mycophenolate, tacrolimus, prednisone, and corticosteroids.
Ashwagandha might make people drowsy or sleepy. So combining sedative-hypnotic medications (used to help with sleep) with ashwagandha might make people too sleepy. Examples of these sedatives are zoldipem, eszoplicone, clonazepam, quetiapine, and lorazepam.
Ashwagandha may increase thyroid hormone levels, so doctors carefully monitor thyroid function by ordering blood tests for anyone who takes thyroid hormones and ashwagandha at the same time.
https://www.merckmanuals.com/home/special-subjects/dietary-supplements-and-vitamins/ashwagandha#Evidence_v61150600Also, check to see if ashwagandha is the only active ingredient. I looked at an ashwaganda powder supplement and found it contained two other ingredients which interacted with the only two Rx medications I'm taking. No such info found on the product itself.
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