First Americans

I've read some about the historical tolerance of Native Americans for people who did not feel they fit into the strict Male or Female mode assigned by birth and how those persons were still giving a place in the tribe where they could contribute, but I'd never heard of this specific term for it was Two-Spirit.

I think a fictional novel I read had a Berdache in it, which was a male who identified as female and in his way was a very important person in the tribe.

Then of course once you know something exists, you spot other articles or hear about it in other places.