Since your computer's going to be rendering the same image twice, at two slightly different angles, you need a fairly robust machine to handle that kind of rendering. If you have that, though, it should be rather smooth animation-wise.
It's not something that one should jump into for six to eight hours a day. Especially since this is a whole new experience for people.
I haven't seen many articles that address the VR-motion sickness issue yet. I'll look around and see what I can find.
On edit: Valve boss Gabe Newell says 'zero percent of people' get nauseous using the Vive VR headset
Speaking in an interview at GDC, Valve boss Gabe Newell said that until now VR headsets have been the "world's best motion sickness inducers," but that "zero percent of people get motion sick" when using his company's headset. That's partly thanks to its Lighthouse motion-tracking system, which is capable of tracking users accurately as they move around a space. In The Verge's hands-on experience with the Vive at GDC, Lighthouse was able to give a highly precise picture of what the wearer was doing in a 3D space, a feature that helps our brains cope with the disconnect between actual physical motion and the virtual world our eyes see.
Take that with a grain of salt, since it
is Gabe Newell speaking. I'd expect the CEO of Valve to be completely supportive of a product his company is making.
But the Lighthouses and their tracking abilities are one of the reasons I went with the Vive.