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elleng

(137,747 posts)
2. 'Sepsis is viewed as a complex chain of systemic events
Sat May 14, 2022, 11:53 PM
May 2022

in response to invading pathogens involving inflammatory and anti-inflammatory processes, humoral and cellular reactions and circulatory dysfunctions. This immune storm leads to organ dysfunction and finally to multiple organ dysfunction syndrome (MODS) and death.'

https://journals.lww.com/co-criticalcare/Abstract/2011/04000/Multiple_organ_failure_in_sepsis__prognosis_and.12.aspx#:~:text=Sepsis%20is%20viewed%20as%20a,syndrome%20(MODS)%20and%20death.

Multiple organ dysfunction syndrome (MODS) is a continuum, with incremental degrees of physiologic derangements in individual organs; it is a process rather than a single event. Alteration in organ function can vary widely from a mild degree of organ dysfunction to completely irreversible organ failure. The degree of organ dysfunction has a major clinical impact.

In a classic 1975 editorial by Baue, the concept of “multiple, progressive or sequential systems failure” was formulated as the basis of a new clinical syndrome. [1] Several different terms were proposed thereafter (eg, multiple organ failure, multiple system organ failure, and multiple organ system failure) to describe this evolving clinical syndrome of otherwise unexplained progressive physiologic failure of several interdependent organ systems

https://emedicine.medscape.com/article/169640-overview

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