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Showing Original Post only (View all)More Than Just a High: The Cannabis-Schizophrenia Link - YALE School of Medicine [View all]
The link between cannabis and its effects on mental health, particularly schizophrenia, continues to spark debate. While many tout marijuanas calming effects, particularly in online forums, mental health experts caution against its useespecially among young people. Research increasingly reveals a concerning relationship between cannabis use and psychotic disorders like schizophrenia.
Beyond the high associated with marijuana, many users report paranoia or hallucinations while under the influence. This is due to the active component, Tetrahydrocannabinol (THC). THC binds to receptors in the brain and triggers a series of reactions in brain cells. Typically, these effects fade after the high wears off, but in some cases, they may last longer, leading to whats known as cannabis-induced psychosis.
In high-risk individuals, cannabis can disrupt brain development and lead to conditions like schizophreniaa severe mental illness characterized by long-term hallucinations, delusions, and paranoia. A Finnish study of 18,000 individuals with cannabis-induced psychosis found that nearly 50% were later diagnosed with schizophrenia (1). Other studies confirm that regular use, especially of high-potency products, increases the risk of developing schizophrenia by four times (2). This risk is comparable to the relationship between high cholesterol and heart disease.
The Specialized Treatment Early in Psychosis (STEP) program at Yale found that over 75% of patients with early schizophrenia had a history of cannabis use, further cementing this link (3).
Beyond the high associated with marijuana, many users report paranoia or hallucinations while under the influence. This is due to the active component, Tetrahydrocannabinol (THC). THC binds to receptors in the brain and triggers a series of reactions in brain cells. Typically, these effects fade after the high wears off, but in some cases, they may last longer, leading to whats known as cannabis-induced psychosis.
In high-risk individuals, cannabis can disrupt brain development and lead to conditions like schizophreniaa severe mental illness characterized by long-term hallucinations, delusions, and paranoia. A Finnish study of 18,000 individuals with cannabis-induced psychosis found that nearly 50% were later diagnosed with schizophrenia (1). Other studies confirm that regular use, especially of high-potency products, increases the risk of developing schizophrenia by four times (2). This risk is comparable to the relationship between high cholesterol and heart disease.
The Specialized Treatment Early in Psychosis (STEP) program at Yale found that over 75% of patients with early schizophrenia had a history of cannabis use, further cementing this link (3).
More at: YALE School of Medicine
I'm sharing this as a caution, in part due to the tragedy of Rob Reiner. His son was of the impression that he could be 'California sober' and continue to use weed, without any ill effects. While this may be true for most, it's not true for everyone.
I personally witnessed a family member experience psychosis from repeated, regular 'pot' use and once the weed smoking stopped, so did the hospitalizations. It's been nearly 30 years of relative peace since my family member stopped smoking pot. This person continues to take medication for bipolar/schizoaffective disorder but has not gone off the rails. At one time she was diagnosed with paranoid schizophrenia, including homicidal tendencies.
That said, I am not suggesting that smoking or ingesting cannabis played a role in what happened to Rob Reiner - but it may have. I also believe that as THC is legalized, we'll have more data/better data in the long run.
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More Than Just a High: The Cannabis-Schizophrenia Link - YALE School of Medicine [View all]
mzmolly
Dec 2025
OP
It isn't "reefer madness" to point out the marijuana of today isn't like the 1960s,
valleyrogue
Dec 2025
#8